College football Week 4 odds, schedule: Pac-12 showdowns, Ohio State-Notre Dame highlight loaded slate

SOUTH BEND, IN - SEPTEMBER 16: Notre Dame Fighting Irish quarterback Sam Hartman (10) celebrates after throwing the football for a touchdown in action during a game between the Notre Dame Fighting Irish and the Central Michigan Chippewas on September 16, 2023 at Notre Dame Stadium in South Bend, IN. (Photo by Robin Alam/Icon Sportswire via Getty Images)
By Dan Santaromita
Sep. 18, 2023

If you thought last week’s college football schedule was lacking, this week makes up for it on paper. Six games feature two AP Top 25 teams and that doesn’t even include the big ACC showdown between the Florida State Seminoles and the now unranked Clemson Tigers.

Despite being unranked and already producing an uninspiring performance against the Duke Blue Devils, Clemson is nearly minus odds on the moneyline at home. FSU is favored by 1.5 points on BetMGM.


Elsewhere, the Pac-12, arguably the best conference in college football this year, has three top-25 matchups. After surviving the Colorado State Rams in double overtime, the Colorado Buffaloes face its toughest test of the season in a trip to Oregon. The Ducks are favored by a whopping three touchdowns. Is this the end of the honeymoon phase for Deion Sanders’ team?

The Utah Utes, which have won the Pac-12 the last two years, host the undefeated UCLA Bruins. Quarterback play will be key in that one, with Utah’s Cam Rising yet to play this season due to injury and five-star freshman Dante Moore is lighting it up for the Bruins so far. Utah is favored but by less than a touchdown.

Then there’s the Pac-12 leftovers bowl between the Oregon State Beavers and the Washington State Cougars. Both are undefeated, but the Beavers are a small favorite on the road.

Read more: College football Week 4 odds and picks against the spread

The main event for the week on paper is the Ohio State-Notre Dame game. The Buckeyes travel to South Bend and are favored by a field goal. This top-10 matchup is a massive early-season test for both teams. It’s the biggest game on Notre Dame’s schedule and the first true proving grounds for new OSU quarterback Kyle McCord.

Here are the odds for every other game featuring an AP top 25 team this week, plus a few other notable matchups.

All odds via BetMGM. All games on Saturday unless otherwise indicated and kickoff times are Eastern. Rankings from the AP poll.

Wisconsin at Purdue — Friday, 7 p.m.

Rutgers at No. 2 Michigan — Noon

No. 4 Florida State at Clemson — Noon

No. 16 Oklahoma at Cincinnati — Noon

Auburn at Texas A&M — Noon

No. 19 Colorado at No. 10 Oregon — 3:30 p.m.

No. 22 UCLA at No. 11 Utah — 3:30 p.m.

No. 15 Ole Miss at No. 13 Alabama — 3:30 p.m.

No. 18 Duke at UConn — 3:30 p.m.

No. 20 Miami at Temple — 3:30 p.m.

BYU at Kansas — 3:30 p.m.

UTSA at No. 23 Tennessee — 4 p.m.

Arkansas at No. 12 LSU — 7 p.m.

No. 14 Oregon State at No. 21 Washington State — 7 p.m.

Charlotte at No. 25 Florida — 7 p.m.

UAB at No. 1 Georgia — 7:30 p.m.

No. 3 Texas at Baylor — 7:30 p.m.

No. 6 Ohio State at No. 9 Notre Dame — 7:30 p.m.

No. 24 Iowa at No. 7 Penn State — 7:30 p.m.

No. 17 North Carolina at Pitt — 8 p.m.

UCF at Kansas State — 8 p.m.

No. 5 USC at Arizona State — 10:30 p.m.

Cal at No. 8 Washington — 10:30 p.m.

(Photo of Sam Hartman: Robin Alam / Icon Sportswire via Getty Images)

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Dan Santaromita

Dan Santaromita is a staff editor for sports betting at The Athletic. Dan previously wrote for NBC Sports Chicago and ProSoccerUSA. He is a University of Missouri graduate who resides in Chicago. Follow Dan on Twitter @TheDanSanto